As far as you need to be concerned as a .NET developer, you can freely interchange them as and when you feel like it.
Latest .NET Framework Classes Articles
Learn about the COM Interoperability improvements coming with the .NET Framework 4.0 and how they will make your COM Interop such as Office applications much easier.
Discover how CCR can work with the .NET Ping class APM functions.
An ADO.NET Data Services Tutorial covering REST, querystring operations and expressions, HTTP verbs, Linq to Data Services, security, exceptions and tracing.
This tip looks at properly closing a WCF connection from your application - whether you're using the proxy classes or a ChannelFactory.
Learn about several features relevant to developers in Visual Studio 2010 and the .NET Framework 4.0, such as parallel programming, XSLT debugging, new ASP.NET features, and new VB.NET and C# features that include the Chart control, XSD Designer, Lambda Expressions, and optional parameters.
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Learn more about a few commonly used components and explore their utility and usages.
Learn how to create a new project for a 3D game, add a simple object to your 3D world, and build a UWP application from this project.
It's easy it is to make a Reversi game in Visual Basic. Learn how here.
Application Programming Interfaces (APIs) are where you have to be. It's not a matter of if as much as a matter of which.