As far as you need to be concerned as a .NET developer, you can freely interchange them as and when you feel like it.
Latest .NET Framework Classes Articles
Learn about the COM Interoperability improvements coming with the .NET Framework 4.0 and how they will make your COM Interop such as Office applications much easier.
Discover how CCR can work with the .NET Ping class APM functions.
An ADO.NET Data Services Tutorial covering REST, querystring operations and expressions, HTTP verbs, Linq to Data Services, security, exceptions and tracing.
This tip looks at properly closing a WCF connection from your application - whether you're using the proxy classes or a ChannelFactory.
Learn about several features relevant to developers in Visual Studio 2010 and the .NET Framework 4.0, such as parallel programming, XSLT debugging, new ASP.NET features, and new VB.NET and C# features that include the Chart control, XSD Designer, Lambda Expressions, and optional parameters.
Latest Developer VideosMore...
Latest CodeGuru Developer Columns
It's essential to know the differences in these libraries and use them correctly. This brief tutorial will guide you.
Learn about a very nice combination of technologies: Entity Framework Core 1.0, SQLite, and a console application.
Learn how to build a basic plug-in framework into your existing applications.
Application Programming Interfaces (APIs) are where you have to be. It's not a matter of if as much as a matter of which.